At the Apple developer conference WWDC 2018, Apple announced that macOS Mojave (10.14) will become the last version of macOS to support 32-bit applications. Click Here for more information about this change.
The current 32-bit version of the Epson Scan application for scanners and all-in-one printers will no longer function in after macOS 10.14.
The Epson Scan 32-bit application will be replaced by Epson Scan 2 for some scanners and all-in-one printers and this is expected to be released by May 2019. After this date all Epson Scan versions released by will be of the 64-bit variant.
Install Epson Scan 2 or an ICA driver (if no Epson Scan 2 download is available):